The evolution of tumor metastases during clonal expansion
نویسندگان
چکیده
منابع مشابه
The evolution of tumor metastases during clonal expansion.
Cancer is a leading cause of morbidity and mortality in many countries. Solid tumors generally initiate at one particular site called the primary tumor, but eventually disseminate and form new colonies in other organs. The development of such metastases greatly diminishes the potential for a cure of patients and is thought to represent the final stage of the multi-stage progression of human can...
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Knudson's two-hit hypothesis proposes that two genetic changes in the RB1 gene are the rate-limiting steps of retinoblastoma. In the inherited form of this childhood eye cancer, only one mutation emerges during somatic cell divisions while in sporadic cases, both alleles of RB1 are inactivated in the growing retina. Sporadic retinoblastoma serves as an example of a situation in which two mutati...
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ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 2010
ISSN: 0022-5193
DOI: 10.1016/j.jtbi.2009.11.005